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Murphy, P.T.; Wells, R.J.Tetrahedron Lett.1978, 19, 4945.8Bioactive Marine NucleosidesAbstractThe chapter deals with the bioactive marine nucleosides.The chemistry and biologicalactivities of spongothymidine, spongouridine, spongosine, isoguanosine, doridosine,22 -deoxythymidine, 2-deoxycytidine, 3-methyl-22 -deoxycytidine, 3-methyl-22 -deoxyuridine, 2'-deoxyadenosine, 22 -deoxyspongosine, 9-[5-deoxy-52 -(methylthio)-²-D-xylofuranosyl]adenine, 5-iodo-52 -deoxy-tubercidin, mycalisine-A, mycalisine-B and 5-deoxy-52 -dimethylarsinyladenosine, 22 , 32 -didehydro-22 , 32 -dideoxyuridine,aplysidine and phidolopin have been discussed.The biological activities of analogsof spongouridine and spongosine have been reviewed.1.IntroductionNucleosides, the nitrogen glycosides of purines and pyrimidines and theirphosphate esters known as nucleotides, are vital components of all livingcells and are involved in several biological processes.Discoveries made inthe area of purine and pyrimidine nucleosides and nucleotide chemistry havecontributed substantially to a better understanding of biology at the molecularlevel.The pioneers of nucleosides chemistry had an interest not only in thenaturally occurring nucleosides and their biochemical properties but also inthe effects of synthetic nucleosides on living organisms.Abnormal purinemetabolism causes a number of human diseases, and specific inhibitors arefound effective in the treatment of some human diseases.Allopurinol, asubstituted pyrazolo[3,4-d]pyrimidine is used clinically for the treatment ofgout and other conditions of rapid purine catabolism
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